Cholinergic network modulation in disinhibited eating behaviour
- Conditions
- disinhibited eating behaviourE66Obesity
- Registration Number
- DRKS00010927
- Lead Sponsor
- niversitätsklinikum Leipzig AöRKlinik und Poliklinik für Nuklearmedizin
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 37
obese: BMI > 35 kg/m²; healthy control: BMI < 25 kg/m2
- age between 18-65 years; ? / ?
- non-smoking
- current or past neurological or psychiatric disease, (i.e. depression and anxiety)
- neurosurgical interventions
- structural tissue lesions in the braín (e.g. stroke, trauma)
- use of anorexic medication or other interventions for weight loss in the past 6 months
- prescription medication (i.e. neurotropic drugs);
- past or present history of alcohol misuse or the use of illegal drugs (ensured by means of psychological tests and urine Screening)
- known cognitive deficits or speech impairment
- simultaneous participation in any other interventional clinical study according to the German Medicinal Products Act (MPA)
- pregnancy and breast-feeding (or other contraindications for the use of radiotracers)
- MRI contraindications such as ferro-magnetism, or claustrophobia
Study & Design
- Study Type
- observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The primary outcome of our study is the quantitatively determined availavbility of the central a4ß2*-nAChR (binding potential and distribution volume ratio) in the human brain.
- Secondary Outcome Measures
Name Time Method MRI-(resting state; task-related fMRI data, especially markers of connectivity), behavioural (impulsivity, cognition, social development) as well as hormonal (leptin, ghrelin, insulin) Parameters and their correlation with a4ß2*-nAChR binding potential and distribution volume ratio.