Does upregulation of microRNA 'x' influence monocyte function of smoking individuals with subclinical atherosclerosis?

Completed

• Conditions: atherosclerosis; cardiovascular disease; 10011082; 10003216

• Registration Number: NL-OMON40682
• Lead Sponsor: Academisch Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 23 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 30

Inclusion Criteria

- smoking
- known calcium score assessed with a coronary CT scan
- known microRNA 'x' levels

Exclusion Criteria

Patients in which statin therapy is a necessity according to standard European guidelines.

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>monocyte function by FACS analysis and cytokine measurement after LPS<br /><br>stimulation. Moreover, we will perform ChIP analysis for epigenetics and<br /><br>measure gene expression levels in the monocytes. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>none </p><br>