Clinical impact of leak compensation during non-invasive ventilatio

• Conditions: non-invasive positive pressure ventilation NPPVCOPD; J44; Other chronic obstructive pulmonary disease

• Registration Number: DRKS00000031
• Lead Sponsor: niversitätsklinikum Freiburg

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Completion: 2006-06-30
• Study Start: 2008-09-05
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 17

Inclusion Criteria

Stable hypercapnic COPD-patients who were already treated with home mechanical ventilation in the pressure-limited mode where included. Patients suffered from COPD stage IV according to GOLD-critiria. Mechanical ventilation was performed for at least two months and patients were admitted to hospital for routine control visit of NPPV.

Exclusion Criteria

Patients who had evidence of acute respiratory failure (e.g. worsening symptoms during the last 2 weeks, a breathing frequency (fb) >30/min, a pH <7.35, or signs of respiratory infections) were excluded.

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Differences in ventilation Patterns during NPPV regarding different ventilator strategies:<br>Volumes for inspiration (V-insp), expiration (V-exp), and leakage (V-leak) as well as peak inspiratory pressures (PIP).<br>

Secondary Outcome Measures

Name	Time	Method
Dyspnea