The Effect of Premedication on Postoperative Pain and Anxiety in Breast Cancer Surgery

Recruiting

• Conditions: Female Patients Under the Age of 65 Who Will Undergo Breast Cancer Surgery
• Interventions: Drug: Precedex and dormicum

• Registration Number: NCT05647642
• Lead Sponsor: Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital

Brief Summary

In this study, it was investigated whether the premedication drug administered before the surgery had an effect on postoperative pain and anxiety scores in female patients under the age of 65 who will undergo breast cancer surgery.

Detailed Description

In this study, it was investigated whether the premedication drug administered before the surgery had an effect on postoperative pain and anxiety scores in female patients under the age of 65 who will undergo breast cancer surgery. The STAI-1(State Trait Anxiety İnventory ) form and APAIS (Amsterdam Preoperative Anxiety and İnformation Scale) scale were filled in for all preoperative patients. Afterwards, the patients were treated with either midazolam or dexmedetothymidine, depending on the anesthesiologist's preference. After administration, he was taken to surgery. As intraoperative analgesics, 2 mg/kg tramadol and 15 mg/kg paracetamol were administered to all patients. postoperative recovery time (aldrete 10), 1., 2.,6.,12.,24. VAS score, postoperative nausea-vomiting scale, STAI-1(State Trait Anxiety İnventory ) form, first need time if postoperative analgesic was needed, and 24-hour total analgesic consumption were recorded. It was aimed to examine the effects of different premedications on postoperative pain and anxiety

Study Timeline

• Study Start: 2022-10-16
• Primary Completion: 2022-11-28
• Status Verified: 2022-12
• Study First Submitted: 2022-12-03
• Study First Submitted QC: 2022-12-03
• Last Update Submitted: 2022-12-03
• Study First Posted: 2022-12-12
• Last Update Posted: 2022-12-12
• Study Completion: 2023-01-30

Recruitment & Eligibility

• Status: RECRUITING
• Sex: Female
• Target Recruitment: 80

Inclusion Criteria

• ASA 1-2-3
• 18-65 aged
• Female patients

Exclusion Criteria

• Under 18 years old and over 65 years old
• Having a history of cerebrovascular disease illiteracy
• Have visual and auditory problems İnability to cooperate with cognitive function test
• Having emergency surgery
• Those who are unable to read, understand and sign the consent form
• Patients deemed unsuitable by the investigator

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
low dose dexmedetothymidine	Precedex and dormicum	0.5 mg/kg dexmedetothymidine 10 minute infusion
low dose midazolam	Precedex and dormicum	0,025 mg/kg Midazolam
high dose midazolam	Precedex and dormicum	0,05 mg/kg Midazolam
high dose dexmedetothymidine	Precedex and dormicum	1mg/kg dexmedetothymidine 10 minute infusion

Primary Outcome Measures

Name	Time	Method
effect of premedication on postoperative pain and anxiety scores	November 2022-December 2022

Trial Locations

Locations (1)

AbdurrahmanYAOTRH; 🇹🇷 Ankara, Turkey