Comparison of two different regimens of naloxone in treatment of methadone-overdosed addicted patients
Phase 2
- Conditions
- Opioid Poisoning.T40
- Registration Number
- IRCT2016041710133N2
- Lead Sponsor
- Toxicological Research Center-?Shahid Beheshti University of Medical Sciences-Vice Chancellor for Re
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 100
Inclusion Criteria
Inclusion Criteria:
Addicted methadone-overdosed patients referring; Positive signs and symptoms of methadone overdose (miosis/respiratory depression/loss of consciousness)
Exclusion Criteria
Age younger than 12 years and older than 65 years; previous history of cardiovascular disease; history of respiratory complications due to naloxone; emergent situation that mandates immediate intubation
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Reversal of respiratory depression. Timepoint: every 3-5 minutes until reversal of the overdose signs and symptoms. Method of measurement: Check vital signs and VBG.
- Secondary Outcome Measures
Name Time Method Occurence of withdrawal syndrome. Timepoint: every 5 to 10 minutes. Method of measurement: check of withdrawal signs and symptoms.