Stress-induced Vascular Dysfunction: Evaluation of Endothelial Function in a Cohort of Patients With Takotsubo Syndrome
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- University of Zurich
- Enrollment
- 44
- Locations
- 1
- Primary Endpoint
- Endothelial function as flow mediated dilatation
Study Overview
Brief Summary
The aim of this prospective single-center study is to evaluate endothelial function, arterial compliance, sympathetic nervous activity at rest and after mental and physical stress, carotid atherosclerosis, oxidative stress parameters, quality of life and platelet adhesion in patients with apical ballooning syndrome and age-matched controls.
Detailed Description
The aim of this prospective single-center study is to evaluate endothelial function, arterial compliance, sympathetic nervous activity at rest and after mental and physical stress, carotid atherosclerosis, oxidative stress parameters, quality of life and platelet adhesion in patients with Takotsubo Syndrome (apical ballooning syndrome/broken heart syndrome) and age-matched controls.
Study Design
- Study Type
- Observational
- Time Perspective
- Prospective
Eligibility Criteria
- Ages
- 18 Years to 80 Years (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- Not provided
Exclusion Criteria
- Not provided
Outcomes
Primary Outcomes
Endothelial function as flow mediated dilatation
Time Frame: baseline
Evaluation of endothelial function as flow mediated dilation in patients with apical ballooning syndrome and controls matched for age and cardiovascular risk factors
Secondary Outcomes
- Evaluation of vascular compliance as pulse wave analysis(baseline)
- Evaluation of pulse wave velocity(baseline)
- Evaluation of carotid atherosclerosis as intima-media-thickness and total plaque area(baseline)
- Measurement of sympathetic nervous activity(baseline)
- Evaluation of platelet adhesion(baseline)
- Evaluation of oxidative stress parameters(baseline)
- Evaluation of tissue factor plasma level(baseline)
- Assessment of quality of life and perceived stress, anxiety and depression(baseline)