Red cell antibody profile in Covid-19
- Conditions
- Health Condition 1: B972- Coronavirus as the cause of diseases classified elsewhere
- Registration Number
- CTRI/2020/10/028567
- Lead Sponsor
- Seth GS Medical College and KEM Hospital
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
1)Blood sample must be of covid-19 positive patient. This is mentioned on the requisition form and the RT PCR status will be doubly reconfirmed by calling up the ward.
And
2)At least one of the following:
i)Sample showing blood group discrepancy (Extra serum reactivity) causing difficulty in interpretation of blood groups
ii)Sample showing incompatible crossmatch with at least one donor unit in saline and /or antiglobulin phase
iii)Sample showing positive direct and /or indirect antiglobulin test (any of the grades weak ,1+, 2+, 3+ ,4+)
Blood grouping discrepancy is defined as the situation when the results of forward and reverse blood group do not match , thus giving rise to difficulty in the interpretation of blood group.
1)Sample that was found hemolysed after completion of all the prescribed tests on the sample. This will be assessed by visual inspection as per the existing SOP
2)Inadequate left over sample ( less than 1ml)
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method There is no intervention in the study. <br/ ><br>The expected results: samples are likely to show positive Direct antiglobulin test and presence of cold antibodiesTimepoint: At day 0: Antiglobulin test results and red cell antibody screening will be performed. They are expected to show positive results <br/ ><br> <br/ ><br>At day 4: Type of antibody (warm or cold) and identification of antibody will be performed on the same sample. <br/ ><br> <br/ ><br>At 2 months: Patients clinical profile will be assessed and will be correlated with antibody profile. <br/ ><br> <br/ ><br>
- Secondary Outcome Measures
Name Time Method Antibodies are likely to be associated with severe CovidTimepoint: At 2 months: Presence of antibodies will be correlated with severity of disease