The Red Blood Cell in Patients with Neuroacanthocytosis: an explorative study on regulation of morphology and function of red blood cells of patients with neurodegeneration of the basal ganglia.
- Conditions
- neuroacanthocytosischoreoacanthocytosis1003815810042258
- Registration Number
- NL-OMON38521
- Lead Sponsor
- niversitair Medisch Centrum Sint Radboud
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- Not specified
- Target Recruitment
- 30
Inclusion Criteria
control donors: healthy, 18-55 years old
patients: clinical diagnosis neuroacanthocytosis
Exclusion Criteria
controls: use of medication with a known effect on red blood cells structure and/or function
patients: inability to obtain sufficient data for a clinical diagnosis
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>The main study parameters are characteristics of red blood cell structure and<br /><br>function in vitro:<br /><br>A. deformability in capillary flow conditions.<br /><br>B. deformability in spleen-like conditions.<br /><br>C. cell morphology.<br /><br>D. cell membrane composition.<br /><br>E. metabolic status.<br /><br>F. characteristics and kinetics of erythropoiesis in vitro.<br /><br>G. active signaling pathways. </p><br>
- Secondary Outcome Measures
Name Time Method <p>na</p><br>