The effect of strenuous exercise on coagulation: Hemostatic behaviour before and after Amstel Gold Race

Recruiting

Conditions: hypercoagulability
thrombosis
10018849

Registration Number: NL-OMON40454

Lead Sponsor: Medisch Universitair Ziekenhuis Maastricht

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: Not specified

Target Recruitment: 96

Inclusion Criteria

• Healthy subjects not taking any medication interfering with coagulation that are willing to donate 23 ml of blood via venipuncture and a capillary blood drop via fingerpuncture before and after the Amstel Gold Race.
• Between 18 and 50 years of age. We take 50 year as a maximal age to prevent any co-morbidity that could have an influence on coagulation (like diabetes, atherosclerosis, peripheral arterial disease, *).
• Etnicity will not be included as an inclusion or exclusion criteria.

Exclusion Criteria

• Subjects taking any medication interfering with coagulation.
• Subjects having a cardiovascular disease or any other serious medical problem.
• Subjects below 18 years or above 50 years of age.
• Subjects that smoke.

Study & Design

Study Type: Observational invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Whole blood (WB) will be used for WB-TG, ROTEM, haematocrit, haemoglobin, and<br /><br>platelet count testing. Plasma will be stored for plasma-TG, PT, APTT, dRVVT-X,<br /><br>measurement of the factor concentrations (II, V, VII, VIII, IX, X, XI, XII,<br /><br>fibrinogen, protein C/S), ADAMTS-13, VWF (antigen/activity), D-dimers and a<br /><br>fibrinolysis assay. Additionally, we will also look at the heart frequency,<br /><br>blood pressure and oxygen levels, cardiac biomarkers and a questionnaire on the<br /><br>trainingsstatus of the participants.</p><br>

Secondary Outcome Measures