Does physical exercise increase clotting factor VIII levels in patients with moderate or mild haemophilia A ?

Completed

• Conditions: FVIII deficiency; haemophilia A; 10064477

• Registration Number: NL-OMON35196
• Lead Sponsor: niversitair Medisch Centrum Utrecht

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 12 August 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 20

Inclusion Criteria

• Haemophilia A
• FVIII activity 1-20%.
• 18-40 years of age
• Male
• Normally active
• Able to complete the exercise test without great difficulty

Exclusion Criteria

• History of inhibitors
• No access to standard haemophilia care since birth (e.g. immigration from other country)
• Joint damage which complicates riding a bicycle
• A known medical condition that may deteriorate during strenuous physical activities

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The primary endpoint of this study is the change in FVIII levels because of<br /><br>exercise in moderate and mild haemophilia A patients.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>The secundary endpoints of this study are von Willebrand factor, von<br /><br>Willebrand propeptide and t-PA before and 10 minutes after exercise in moderate<br /><br>and mild haemophilia A patients.</p><br>