25-Hydroxyvitamin D, 1,25-Dihydroxyvitamin D and Postoperative Outcome in Cardiac Surgical Patients
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 3,852
- 试验地点
- 1
- 主要终点
- major cardiac or cerebrovascular event (MACCE)
研究概览
简要总结
We will use a retrospective data analysis to evaluate the association of the two vitamin D metabolites 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D with clinical outcome in cardiac surgical patients. The occurrence of several postoperative adverse events such as myocardial infarction, low cardiac output syndrome, stroke and in-hospital death will be assessed from cardiac surgery to discharge. In addition, we will assess the association of the two vitamin D metaboolites with the duration of mechanical ventilatory support and intensive care unit stay from cardiac surgery to discharge. Moreover, in-hospital stay will be assessed according to vitamin D metabolite levels.
详细描述
In a retrospective data analysis, we will evaluate the association of vitamin D metabolites (circulating 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D) with MACCE (major cardiac or cerebrovascular event) in cardiac surgical patients. The occurrence of several postoperative adverse events such as myocardial infarction, low cardiac output syndrome, stroke and in-hospital death will be assessed from cardiac surgery to discharge. Approximately 4,000 data sets from mid of 2012 until the end of 2013 will be analyzed. In all patients, we will also assess the association of vitamin D metabolite levels with the duration of mechanical ventilatory support and intensive care unit stay from cardiac surgery to discharge. Moreover, in-hospital stay will be assessed according to vitamin D status
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •cardiac surgical patients aged 18 years and older
排除标准
- •age < 18 years
- •heart transplant recipients
- •pacemaker or defibrillator implantation
结局指标
主要结局
major cardiac or cerebrovascular event (MACCE)
时间窗: Patients will be followed for an average time of 14 days from cardiac surgery to discharge
MACCE is defined as in-hospital death, myocardial infarction, low cardiac output syndrome or stroke.
次要结局
- duration of ventilatory support(Patients will be followed for an average time of 14 days from cardiac surgery to discharge)
- in-hospital stay(Patients will be followed for an average time of 14 days from cardiac surgery to discharge)
- intensive care unit stay(Patients will be followed for an average time of 14 days from cardiac surgery to discharge)
- infection(Patients will be followed for an average time of 14 days from cardiac surgery to discharge)