Effect of Endurance and Endurance-Strength Training on Inflammatory Markers in Women With Abdominal Obesity
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 38
- 试验地点
- 2
- 主要终点
- C-reactive protein (CRP) at baseline
研究概览
简要总结
The aim of this study was to compare the effects of three months' endurance training and three months' endurance-strength training on inflammatory markers in women with abdominal obesity.
详细描述
Study patients. Written informed consent was obtained from all subjects. The study meets the standards of the Declaration of Helsinki in its revised version of 1975 and its amendments of 1983, 1989, and 1996.
Study design. The study was designed as a prospective randomized trial. Subjects were randomly divided into two groups, A and B, using a randomization list. Both groups performed three month of physical training. Group A underwent endurance training, while group B performed endurance-strength training. Aside from the training, all subjects were instructed to maintain the physical activity and diet that they had been practicing so far. At baseline and after three months of physical training, blood samples for laboratory analyses were taken, anthropometric measurements were performed for both groups.
Intervention. The exercise program lasted three months, with three sessions per week. Women in both groups participated in a total of 36 training sessions. The women in group A underwent endurance exercise on cycle ergometers (Schwinn Evolution, Schwinn Bicycle Company, Boulder, Colorado, USA). Exercise sessions consisted of a five-minute warm-up (stretching exercise) at low intensity (50%-60% of maximum heart rate), a 45-minute exercise (at 50%-80% of maximum heart rate), five minutes of cycling without a load, and five minutes of closing stretching and breathing exercise of low intensity. Group B performed endurance-strength exercise consisting of a five-minute warm-up (stretching exercises) of low intensity (50%-60% of maximum heart rate), a strength component, an endurance component, 5 minutes cycling without a load, and a 5 minutes closing stretching and breathing exercise of low intensity. The 20-minute-long strength component was performed using a neck barbell and a gymnastic ball. Directly after the strength exercise, the women took part in a 25-minute endurance exercise on cycle ergometers (Schwinn Evolution, Schwinn Bicycle Company, Boulder, Colorado, USA) at 50%-80% of maximum heart rate. Both the endurance and endurance-strength training were comparable in exercise volume; the only difference was the nature of the effort.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •informed written consent;
- •simple obesity;
- •age from 18 to 65 years;
- •body fat content, assessed by electrical bioimpedance, equal to or more than 33%;
- •waist circumference more than 80 cm;
- •stable body weight in the one month prior to the trial.
排除标准
- •secondary form of excess body mass
- •secondary form of arterial hypertension
- •mean systolic blood pressure > 140 mmHg and/or mean diastolic blood pressure > 90 mmHg;
- •diabetes;
- •ischemic heart disease;
- •heart failure;
- •history of malignancy;
- •clinically significant heart arrhythmias;
- •a history of use of any dietary supplement;
- •serious liver or kidney damage;
- •abnormal thyroid gland function;
- •clinically significant inflammation, connective tissue disease, or arthritis;
- •nicotine, alcohol, or narcotic abuse;
- •infection;
- •pregnancy, childbirth, or lactation;
- •any other condition that would make participation not in the best interest of the subject, or could prevent the efficacy of the study.
研究组 & 干预措施
Group A
Endurance training
干预措施: Endurance training (Behavioral)
Group B
Endurance-strength training
干预措施: Endurance-strength training (Behavioral)
结局指标
主要结局
C-reactive protein (CRP) at baseline
时间窗: At baseline
Serum concentration of C-reactive protein at baseline
CRP after three months of physical training
时间窗: after three months of physical training
Serum concentration of C-reactive protein after three months of physical training
次要结局
- Body height at baseline(At baseline)
- tumor necrosis factor alpha (TNFα) at baseline(at baseline)
- TNFα after three months of physical training(after three months of physical training)
- interleukin 6 (IL-6) at baseline(At baseline)
- interleukin 1 (IL-1) at baseline(At baseline)
- Body mass at baseline(At baseline)
- Body height after three months of physical training(after three months of physical training)
- soluble receptor 2 of TNF alpha (sTNF R2) at baseline(At baseline)
- sTNF R2 after three months of physical training(after three months of physical training)
- visfatin after three months of physical training(after three months of physical training)
- IL-6 after three months of physical training(after three months of physical training)
- IL-1 after three months of physical training(after three months of physical training)
- visfatin at baseline(At baseline)
- Body mass after three months of physical training(after three months of physical training)
研究者
Pawel Bogdanski
Professor
Poznan University of Medical Sciences