Immersive Virtual Reality for Dual-task Training in Older Adults With Mild Cognitive Impairment: A Randomized Controlled Trial
- Conditions
- Mild Cognitive Impairment
- Interventions
- Other: Motor single task training (MSTT)Other: Cognitive-motor dual task training (DTT)Other: Cognitive single task training (CSTT)
- Registration Number
- NCT05730790
- Lead Sponsor
- Tan Tock Seng Hospital
- Brief Summary
Mild cognitive impairment (MCI) is a pre-dementia state marked by a higher risk of conversion to dementia. Presently, strategies to delay the progression of MCI to dementia, such as routine exercise and cognitive activities, are limited and only moderately efficacious. Cognitive-motor dual task training, enhanced in a virtual reality environment, is a novel intervention for individuals with MCI.
- Detailed Description
A randomized controlled trial will be conducted. 54 patients with MCI will be recruited from an outpatient clinic. The participants will be randomly allocated to one of the three study arms. All three groups will participate in 2 training sessions per week for 7 weeks. Each session lasts 32 to 40 minutes.
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- All
- Target Recruitment
- 54
- Age 60 - 80 years of age
- Diagnosis of mild cognitive impairment (MCI)
- Able to walk independently without assistance, whether from a person or a walking aid
- Diagnosed dementia (at the point of recruitment)
- Presence of end stage lung, cardiac, liver and/or renal disease
- Unstable acute medical conditions that prevent one from exercising on a treadmill
- Presence of active arthritis, with symptoms affecting function
- Cerebrovascular and/or cardiac events in the last 6 months
- Parkinson's disease
- History of hip fracture within the last 6 months
- History of epilepsy with seizures in the last 2 years
- Poor vision, not correctable by glasses
- Hearing difficulty (if unable to hear well at normal conversational volume)
- Acute backache with pain affecting ambulation
- Acute lower limb pain with pain affecting ambulation
- Cervical spondylosis with myelopathy or cervical spine issues
- Chronic vertigo
- Vestibular problems, causing issues with balance
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Motor single task training (MSTT) Motor single task training (MSTT) Participants attended 14 sessions (40 minutes each) of single task motor training over a period of 7 weeks. Each motor training session comprised of walking on a treadmill, of progressive difficulty pitched to the participant's performance Cognitive-motor dual task training (DTT) Cognitive-motor dual task training (DTT) Participants attended 14 sessions (40 minutes each) of dual task cognitive-motor training, 2 times per week for 7 weeks. Each cognitive-motor training session comprised of performing a dual task activity - gameplay using a virtual reality (VR) system while walking on a treadmill, of progressive difficulty pitched to the participant's performance. Cognitive single task training (CSTT) Cognitive single task training (CSTT) Participants attended 14 sessions (32 minutes each) of single task cognitive training, 2 times per week for 7 weeks. Each cognitive training session comprised of game play using a virtual reality (VR) system, of progressive difficulty pitched to the participant's performance
- Primary Outcome Measures
Name Time Method Change in dual-task gait cost measured using Optogait Baseline, post-intervention after session 14 (week 7), 6 month Gait parameters collected include step length, single support time, double support time, step time, stride length, speed and cadence. Gait parameters are collected under both single and dual-task (serial seven subtraction and animal naming) conditions.
Dual-task cost calculated as 100\*(single task parameter - dual-task parameter)/single task parameterChange in dual-task cognitive cost measured using corrected response rate of cognitive tasks Baseline, post-intervention after session 14 (week 7), 6 month Cognitive tasks include 30 seconds serial seven subtraction and animal naming, under both single and dual-task conditions (while walking)
- Secondary Outcome Measures
Name Time Method Change in number of falls measured using a falls diary Baseline, 6 month Number of falls in the past 12 months
Change in balance parameters and falls risk measured using Berg Balance Scale (BBS) Baseline, post-intervention after session 14 (week 7), 6 month BBS is a 14-item tool which objectively assesses static balance and falls risk.
Change in falls risk measured using Timed Up and Go test (TUG) Baseline, post-intervention after session 14 (week 7), 6 month TUG is a evaluative tool which assesses functional mobility and falls risk
Change in falls concerns scored using the Falls Efficacy Scale International (FES-I) Baseline, post-intervention after session 14 (week 7), 6 month FES-I is a 16-item questionnaire used to measure the level of concern about falling during social and physical activities.
Change in executive function measured using Chinese Frontal Assessment Battery Baseline, 6 month CFAB is brief tool used to assess frontal dysfunction via a series of neuropsychological tasks. A higher score indicates better performance with a total maximum of 18.
Change in executive function scored using the Stroop color-word test - Victoria version (VST) Baseline, 6 month VST assess executive functioning using three conditions that consist in naming color of dots, of neutral words, and of color words printed in incongruent colors.
Change in sustained and divided attention assessed using Color Trails Test 1 and 2 Baseline, 6 month Color Trails Test is the language free version of Trails Making Test, developed for cross-cultural assessment of sustained and divided attention in adults
Trial Locations
- Locations (1)
Tan Tock Seng Hospital
🇸🇬Singapore, Singapore