DRKS00031963
Not yet recruiting
未知
Influence of high-flow nasal cannula versus O2 nasal cannula on parameters of oxygenation and ventilation in small preterm infants in weaning from respiratory support - a prospective randomised clinical trial
niversitätsklinikum Ulm, Klinik für Kinder-und Jugendmedizin, Sektion Neonatologie und pädiatrische Intensivmedizin0 sites60 target enrollmentMay 30, 2023
Overview
- Phase
- 未知
- Intervention
- Not specified
- Conditions
- P22.0
- Sponsor
- niversitätsklinikum Ulm, Klinik für Kinder-und Jugendmedizin, Sektion Neonatologie und pädiatrische Intensivmedizin
- Enrollment
- 60
- Status
- Not yet recruiting
- Last Updated
- last year
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Preterm infants with a gestational age \<32 weeks of gestation and a birth
- •weight \<1500g
- •\- Requirement for non\-invasive ventilation (CPAP or CPAP backup)
- •\- FiO2 on CPAP or CPAP backup 21% \- 60% at a PEEP of 4\-8
- •\- At least 4 hypoxaemias (\< 80% SpO2\) and/or apnoeas (\>20
- •seconds duration) and/or bradycardia (heart rate \<100/min) in the
- •12 hours prior to study entry
- •\- In the 12 hours prior to study entry, the number of
- •irritable/intervention events (defined as SpO2 \< 70% for \> 1min or heart
- •rate for \> 1min or heart rate \< 100/min for \> 30 seconds) did not result in
Exclusion Criteria
- •\- premature and newborn infants with severe malformations that
- •significantly impair respiratory regulation (severe CNS malformations),
- •lung function (e.g. pulmonary hypoplasia, acute extra\-alveolar air such as
- •pneumothorax and pulmonary interstitial emphysema, diaphragmatic
- •hernias) or circulatory function (congenital cyanotic cardiac vitals, severe
- •septic shock)
- •\- postnatal age \<120 hours of life (often acute deterioration in the early
- •phase of respiratory distress syndrome and to protect the minimal
- •handling principle in the critical phase to prevent intraventricular
- •haemorrhage)
Outcomes
Primary Outcomes
Not specified
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