NCT01052818Unknown不适用
Therapeutic and Prognostic Impact of Circulating Tumor Cells in Peripheral Blood in Patients With Non Small-cell Lung Cancer
National Institute of Cancerología1 个研究点 分布在 1 个国家目标入组 200 人开始时间: 2007年7月最近更新:
适应症
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 200
- 试验地点
- 1
- 主要终点
- Response rate, progression-free survival and over-all survival
研究概览
简要总结
The purpose of the study is to evaluate the association between the number of circulating tumor cells and response to treatment in non small-cell lung cancer patients
详细描述
In spite of technological advantages in diagnosis and treatment, lung cancer remains one of the most deadly malignant neoplasias. Moreover, there are no markers for monitoring response to treatment. The objective of the study is to associate the number of circulating tumor cells (CTC) before and after treatment and correlate it with tumor response rate, progression-free survival and overall survival.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Histopathologic diagnosis of non small-cell lung cancer
- •Clinical stage IV
- •ECOG functional status 0 or 1
- •No renal function alteration (GFR >50%)
- •No hepatic function alteration (ALT and AST less than 2 times its normal value)
- •Leucocytes more than 2,000/mcl
- •Hemoglobin more than 10mg/dL
- •Platelets more than 100,000/mcl
排除标准
- •Non-advanced disease
结局指标
主要结局
Response rate, progression-free survival and over-all survival
时间窗: 4 years
次要结局
- Quantification of CTCs(4 years)
研究者
研究点 (1)
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