Genetic regulation of stress responsivity as a risk factor for schizophrenia and bipolar disorder. ;Subtitle: The association of (epi)genetic factors on the hormonal and autonomic stress response after psychosocial stress
Completed
- Conditions
- bipolar I disorder/ manic-depressive illness and schizophrenia10026753
- Registration Number
- NL-OMON39235
- Lead Sponsor
- niversitair Medisch Centrum Utrecht
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 220
Inclusion Criteria
1. Schizophrenia patients (n=50)
2. Bipolar I disorder patients (n=50)
3. Healthy co-twin of monozygous twins discordant for bipolar disorder (n=20)
4. Healthy volunteers groupwise matched for age, gender, smoking, alcohol use, caffeine intake and drug use (n=50)
5. Healthy siblings of bipolar I disorder patients (n=50)
Exclusion Criteria
General exclusion criteria are:
- speech impairments
- lack of fluency in the Dutch language
- Less than 3 Dutch grand parents;Acute exclusion criteria are:
- any acute illness
- having a severe cold
- recent physical exertion within the last 2 hours
- large meal within the last 2 hours
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>Hormonal stress response: stress-induced saliva cortisol </p><br>
- Secondary Outcome Measures
Name Time Method <p>* Autonomic stress response<br /><br>o Heart rate (variability)<br /><br>o Body temperature<br /><br>o Alpha-amylase (saliva)<br /><br><br /><br>* Immune response<br /><br>o Saliva<br /><br>o Blood<br /><br><br /><br>* Performance on a number of cognitive tasks<br /><br>* Perceived Stress (questionnaires)<br /><br>* Genotype and genetic expression of psychiatric risk genes and genes involved<br /><br>in the stress system<br /><br>* Epigenetic DNA methylation of 27,000 loci van het genoom.</p><br>