Genetic vulnerability to stress across psychiatric diagnoses. Schizophrenia and Major Depressive Disorder
- Conditions
- psychiatrische aandoeningenmood disorderpsychosis
- Registration Number
- NL-OMON31500
- Lead Sponsor
- niversitair Medisch Centrum Utrecht
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Withdrawn
- Sex
- Not specified
- Target Recruitment
- 90
Subjects have to satisfy the following criteria in order to participate in the study:
- Give written informed consent
- Aged between 18-65 years of age;Specific for schizophrenia patients:
- Do have a DSM-IV diagnosis of Schizophrenia
- Do not chronically use medication, other than psychiatric medication
- Are not in an acute psychotic episode, but stable for at least 6 months;Specific for MDD patients:
- Do have a DSM-IV diagnosis of Major Depressive Disorder
- Do not chronically use medication, other than psychiatric medication
- Are not in an acute depressive episode, but stable for at least 6 months
- Have had at least two depressive episodes and at least one hospital admission due to affective symptoms
- Ferrous objects in or around the body (e.g. braces, pacemaker, metal fragments)
- Claustrophobia
- Drug or alcohol abuse over a period of six months prior to the experiment
- History of closed-head injury
- History of neurological illness or endocrinological dysfunction
- A pacemaker;Specific for the healthy individuals:
- A psychiatric history
- Chronic use of medication
- A first-degree family member with a psychiatric illness
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>The main study parameter is the relationship between susceptibility to stress<br /><br>(cortisol response after a psychosocial stressor) and structural and functional<br /><br>brain measurements, and how this association is medicated by genotype (COMT,<br /><br>5HTTLPR). </p><br>
- Secondary Outcome Measures
Name Time Method <p>n/a</p><br>