The influence of stress and lifestyle in hereditary angioedema

Not Applicable

Completed

• Conditions: Hereditary angioedema; Human Genetics and Inherited Disorders - Other human genetics and inherited disorders; Skin - Other skin conditions; Inflammatory and Immune System - Other inflammatory or immune system disorders

• Registration Number: ACTRN12621000473864
• Lead Sponsor: niversity of Auckland

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2021-04-21
• Study Completion: 2022-03-08
• Last Update Posted: 12 December 2022

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 3

Inclusion Criteria

Inclusion criteria – people who:
1.Have been diagnosed by a Clinical Immunologist, to be suffering from hereditary angioedema which does not respond to antihistamine or corticosteroid treatment (determined by family history, presence of symptoms of angioedema, low C1 inhibitor level or function or genetic studies)
2.Have access to on-demand medication
3.Are aged 18 and above
4.Are currently and for the duration of the study, residing in New Zealand
5.Have access to a computer and internet connection to access the online intervention

Exclusion Criteria

Exclusion criteria – people who:
1.Are unable to comprehend the information sheet and the consent form or unable to give consent.
2.Are participating in another clinical trial
3.Are engaged in another lifestyle intervention, such as working with a health professional on making lifestyle changes
4.Have acquired angioedema
5.Do not have access to on-demand medication
6.Are aged 17 or less
7.Reside outside of New Zealand or planning to during the study
8.Do not have access to a computer and / or do not have access to an internet connection

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
ifestyle quality score (comprising Firstbeat Lifestyle Assessment overall lifestyle assessment score, stress and recovery balance score, restorative effect of sleep score and health effects of physical activity score)[Week 1, Week 13 and follow-up at week 25];Quality of life measured by the HAE Quality of Life Questionnaire (AE-QoL)[Week 1, Week 13 and follow-up at week 25];Swelling attack activity measured by the Angioedema Activity Score Questionnaire (AAS)[Week 1, Week 13 and follow-up at week 25]