Randomized control trial to study the impact of weight bearing and resistance exercise with nutritional interventions on bone and muscle health in obese patients with osteosarcopenia

1.      Osteosarcopenia is a relatively new entity that describes the co-existence of osteoporosis and sarcopenia which are associated with ageing. In addition to aging, osteosrcopenia is also associated with obesity. Osteosarcopenic obesity is a condition of growing importance with significant negative sequelae on both patients and society alike. Osteoporosis, a condition of low bone mass and mineralization of bone; sarcopenia, the loss of muscle mass, strength and function, and obesity, increased adipose tissue in body leading to significantly worsened outcomes than seen in either condition individually. For individuals, major consequences include falls and fractures, increased morbidity, mortality and disability, and reduced quality of life. For society, osteosarcopenia brings a staggering socioeconomic burden. With increasing age and obesity in population, osteosarcopenic obesity becomes a public health concern. Its aetiology is multi-factorial, with mechanical, biochemical, genetic and lifestyle factors all contributing to involution of the “bone-muscle- unit†and increasing adipose tissue. Increasing understanding of the interactions between muscle, bone and adipose tissue could facilitate the development of new therapeutic agents to mitigate the impact of these on individual’s health. Therefore, it is the urgent need of the hour for early diagnosis of osteosarcopenia in young obese population for effective therapeutic interventions. Together with existing pharmacological, nutritional and exercise-based therapies, the present proposal aim to provide non pharmacological management of osteosarcopenia using resistance exercise and nutritional intervention in osteosarcopenic obese patients.