Treatment study psychotrauma: Medication versus psychotherapy.Behandelstudie psychotrauma: Medicatie versus psychotherapie.

Recruiting

• Conditions: SSRI; CBT; Posttraumatic Stress Disorder (PTSD); cost-effectiveness

• Registration Number: NL-OMON29379
• Lead Sponsor: Academic Medical Center, University of Amsterdam

Brief Summary

/A

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 28 February 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: Not specified
• Target Recruitment: 234

Inclusion Criteria

1. Patients with a diagnosis of chronic PTSD (> 3 months);

2. CAPS score of 45 and higher;

Exclusion Criteria

1. Suicidal risk;

2. Presence of any of the following DSM IV diagnoses: Psychotic disorder incl. schizophrenia, a bipolar disorder, depression with psychotic features, or excessive substance related disorder over the past 6 months;

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
1. The change in Clinician Administered PTSD Scale (CAPS) at 1 week, 3 months, 6 months, 12 and 18 months after treatment;<br /><br>2. (Unit) costs associated with an improved PTSD outcome in terms of CAPS scores at 1 week, 3 months, 6 months and 12 and 18 months after treatment.

Secondary Outcome Measures

Name	Time	Method
At 1 week, and 3, 6, 12 and 18 months post-intervention the following secondary outcomes will be assessed as well:<br /><br>1. Other psychopathology;<br /><br>2. Quality of life;<br /><br>3. Anxiety and depression and costs;<br /><br>4. Neurocognitive, neuroimmune and genetic measures.