Changes in DNA (epigenetics) and in the behavioral, emotional and conscience aspects of women with painful Temporomandibular Disorders before and after a Mindfulness program

Phase 1

Suspended

• Conditions: Temporomandibular Joint Dysfunction Syndrome; C05.500.607.221.897.897

• Registration Number: RBR-5mvjqt
• Lead Sponsor: niversidade de São Paulo-Faculdade de Filosofia Ciências e Letras de Ribeirão Preto

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2020-10-04
• Last Update Posted: 29 May 2023

Recruitment & Eligibility

• Status: Suspended
• Sex: Female
• Target Recruitment: Not specified

Inclusion Criteria

Volunteer women; age between 18 and 45 years; diagnosis of painful TMD for more than 3 months.

Exclusion Criteria

Volunteers undergoing any type of treatment for painful Temporomandibular Dysfunction; previous history of tumors; previous history of trauma or head and neck surgery; presence of neurological disorders; presence of psychiatric disorders; volunteers who use controlled medications, such as anxiolytics, antidepressants and anticonvulsants; pregnant volunteers.

Study & Design

• Study Type: Intervention
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Painful reduction resulting from chronic painful Temporomandibular Disorder,immediately after the end of the intervention, as well as epigenetic changes. Pain reduction will be assessed by quantitative sensory tests such as the pressure pain threshold and hyperalgesia (using a digital algometer) and allodynia (using a rotating electric toothbrush, with a 5-second stimulation). The three tests will be applied at the same pre points -determined). The epigenetic analysis will be performed by global DNA methylation and by methylation analysis of single nucleotide polymorphisms (SNPs), previously identified related to chronic painful temporomandibular disorder.

Secondary Outcome Measures

Name	Time	Method
Cognitive-behavioral-emotional changes, measured by validated, self-applicable and specific protocols. They will be evaluated immediately after completion of the intervention.