NCT05506098已完成不适用
Investigating STAT3 as a Driver of Pathology and Potential Therapeutic Target in Periodontitis
University of Chile1 个研究点 分布在 1 个国家目标入组 28 人开始时间: 2019年3月20日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 28
- 试验地点
- 1
- 主要终点
- STAT3 detection in gingival tissues
研究概览
简要总结
Periodontitis is a prevalent inflammatory condition that destroys tooth-supporting structures. This condition is associated with pro-inflammatory mediators that utilize STAT3 as an activator of specific genes related to inflammation and tissue destruction. STAT3 has not been studied in the context of periodontitis in humans. We propose that STAT3 is associated with periodontitis. This knowledge might help to further our understanding of periodontitis pathology
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •18-year-old, in good general health, and had no significant medical history.
- •no history of diabetes or other diseases different than periodontitis.
排除标准
- •Pregnancy and lactation
- •Use of antibiotics, immunosuppressive agents, or probiotics within 3 months.
结局指标
主要结局
STAT3 detection in gingival tissues
时间窗: 1 day
Detection of STAT3 in gingival tissues
次要结局
未报告次要终点
研究者
Nicolas Dutzan
Associate Professor
University of Chile
研究点 (1)
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