Effects of the food matrix on serum fructose peaks

Recruiting

Conditions: High blood pressure
Hypertension
Non-alcoholic fatty liver disease
10019654
10057166

Registration Number: NL-OMON53397

Lead Sponsor: Medisch Universitair Ziekenhuis Maastricht

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: Not specified

Target Recruitment: 26

Inclusion Criteria

Age >= 18 years.
Body mass index (BMI) >=18.5 kg/m2 and <25 kg/m2

Exclusion Criteria

- Pregnancy.
- Drugs and/or alcohol abuse.
- Diagnosis of diabetes mellitus.
- (History of) gastrointestinal and/or liver disease.
- (History of [< 5 years]) Ccancer (excluding basal cell carcinoma).
- Physical stress one month prior to inclusion (i.e. post-surgery, trauma that
requires medical treatment, or bacterial/viral/fungal infection or
extreme psychological stress).
Symptoms of infection include: fever, (excessive) sweating & chills, cough,
sore throat, shortness of breath, nasal congestion, diarrhea, vomiting, painful
miction, redness/swelling, stomach ache, head ache, and stiff neck.
- Unstable weight for 3 months prior to inclusion (i.e. 5% change in
bodyweight)(18).
- Allergy to one of the used food products in the study.
- Inability to provide written informed consent.

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The primary study parameter is the fructose peak, defined as the maximal<br /><br>incremental change from baseline. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Secondary study parameters include:<br /><br>1. Systolic and diastolic blood pressure peak, defined as the maximal<br /><br>incremental change from baseline.<br /><br>2. Serum uric acid peak, defined as the maximal incremental change from<br /><br>baseline. </p><br>