DECREASING THE NEED FOR MECHANICAL VENTILATION AFTER RETINOPATHY OF PREMATURITY SURGERY: Sedation vs General Anesthesia
Overview
- Phase
- Phase 4
- Intervention
- Ketamine
- Conditions
- Retinopathy
- Sponsor
- TC Erciyes University
- Enrollment
- 60
- Primary Endpoint
- Respiratory failure after retinopathy of prematurity surgery in premature infants.
- Status
- Completed
- Last Updated
- 12 years ago
Overview
Brief Summary
Premature infants experience more respiratory problems after surgical procedures. The investigators aimed to compare general anesthesia with sedation on the need for post-operative mechanical ventilation in infants undergoing retinopathy of prematurity surgery.
Detailed Description
60 patients who underwent laser surgery due to retinopathy of prematurity (ROP) were included in the study. The sedation group (Group S, n=30), received 1 mg/kg ketamine and 1 mg/kg propofol as a bolus for induction. The patients then received an infusion of 100-150 mcg/kg/min propofol and 0.25mg/kg/h of ketamine for maintenance. In the general anesthesia group (Group G, n=30), anesthesia was induced using 8% sevoflurane by inhalation with 50% nitrous oxide in oxygen; endotracheal intubation was facilitated without use of a neuromuscular blocker agent. Anesthesia was maintained with sevoflurane (2%) and 50% nitrous oxide in oxygen. Our primary objective was to evaluate the need for post-operative mechanical ventilation.
Investigators
Ayse Ulgey
assistant professor
TC Erciyes University
Eligibility Criteria
Inclusion Criteria
- •infants aged 32-40 weeks who were scheduled to undergo laser surgery for treatment of ROP
Exclusion Criteria
- •The exclusion criteria were patients requiring inotropic support,
- •the need for mechanical ventilation or intubation in the 3 days prior to the operation,
- •known allergy or hypersensitivity reaction to ketamine and propofol,
- •age ˃40 weeks.
Arms & Interventions
sedation
The sedation group (Group S, n=30), received 1 mg/kg ketamine and 1 mg/kg propofol as a bolus for induction. The patients then received an infusion of 100-150 mcg/kg/min propofol and 0.25mg/kg/h of ketamine for maintenance.
Intervention: Ketamine
sedation
The sedation group (Group S, n=30), received 1 mg/kg ketamine and 1 mg/kg propofol as a bolus for induction. The patients then received an infusion of 100-150 mcg/kg/min propofol and 0.25mg/kg/h of ketamine for maintenance.
Intervention: propofol
general anesthesia
In the general anesthesia group (Group G, n=30), anesthesia was induced using 8% sevoflurane by inhalation with 50% nitrous oxide in oxygen; endotracheal intubation was facilitated without use of a neuromuscular blocker agent. Anesthesia was maintained with sevoflurane (2%) and 50% nitrous oxide in oxygen.
Intervention: Sevoflurane
Outcomes
Primary Outcomes
Respiratory failure after retinopathy of prematurity surgery in premature infants.
Time Frame: 1 Day (From end of anaesthesia till discharge from the recovery room )
Most of premature infants have chronic lung disease, for this reason endotracheal intubation causes some problems, because they have irritable airway. Administration of sedation and avoiding endotracheal intubation can be better for postsurgical outcomes. How many infants needed endotracheal intubation and mechanical ventilation were recorded.
Secondary Outcomes
- Blood Pressure(1 Day (From start of anaesthesia till discharge from the operation room))
- Heart rate(1 Day (From start of anaesthesia till discharge from the recovery room ))