Comparison of morphine (strong opioid) with tramadol (weak opioid) in advanced lung cancer patients with moderate to severe pain in terms of quality of life and pain relief at 3 weeks follow up
Phase 2
Completed
- Conditions
- Health Condition 1: J984- Other disorders of lungHealth Condition 2: null- Stage 4 lung cancer patients with moderate to severe pain presenting to pain clinic
- Registration Number
- CTRI/2018/01/011093
- Lead Sponsor
- Dr Sushma Bhatnagar
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 60
Inclusion Criteria
1.Age more than 18 years
2.Either gender
3.Diagnosed with stage 4 lung cancer
4.Patients have agreed to participate in the study and have signed written informed consent.
5.Admitted or attending Palliative care OPD at IRCH
6.Patients already on Step 1 WHO analgesic ladder
7.Opioid-naïve patients
8.NRS >4 (Moderate to severe pain)
9.Somatic, visceral or mixed pain
Exclusion Criteria
1.Diagnosed mental illness or cognitive impairment
2.Patients refusal to give consent/assent to participate in the study
3.Patients with delirium or obtundation
4.Co-existing liver or renal diseases
5.Patients requiring intravenous(IV) drugs or IV morphine titration
6.Pure neuropathic pain
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method â?¢Assessment of quality of life and pain scores in stage 4 lung cancer patients with moderate to severe pain receiving tramadol versus morphine at 3 weeks follow upTimepoint: â?¢Assessment of quality of life and pain scores in stage 4 lung cancer patients with moderate to severe pain receiving tramadol versus morphine at 3 weeks follow up
- Secondary Outcome Measures
Name Time Method 1.Symptom burden in stage 4 lung cancer patients <br/ ><br>2.Association between Numerical rating scale (NRS) scores and QOL <br/ ><br>3.Overall satisfaction of lung cancer patients with treatment. <br/ ><br>4.Percentage of patients started on tramadol but converted to morphine at 3 weeks follow up. <br/ ><br>5.Side effects pattern with tramadol and morphine in lung cancer patients <br/ ><br>6.Cost effectiveness <br/ ><br> <br/ ><br>Timepoint: At 1 and 3 weeks of follow up