Social interaction and social cognition in borderline personality disorder

Recruiting

Conditions: F60.3
F40.1
Emotionally unstable personality disorder
Social phobias

Registration Number: DRKS00009429

Lead Sponsor: Zentralinstitut für Seelische Gesundheit, Universität Heidelberg

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: Female

Target Recruitment: 120

Inclusion Criteria

BPD: = 5 DSM-5 criteria (International Personality Disorder Examination, IPDE)
Social Phobia: DSM-5 diagnosis of social anxiety disorder according to Structured Clinical
Interview for DSM-IV axis I disorders (SCID)

Exclusion Criteria

General exclusion criteria:
- Psychotropic medication two weeks prior to investigations
- Lifetime diagnosis schizophrenia or bipolar I disorder
- Substance dependence within one year prior to study, current substance abuse (verified by
negative urine drug screening)
- Pregnancy
- History of epilepsy, brain trauma, brain tumor, or other significant neurological or medical
condition
- BMI < 16.5
- Metal implants with non-MR-compatible material that cannot be removed
- Permanent make-up
- Claustrophobia
- Left-handedness
Social Phobia: > 2 DSM-IV criteria for BPD (IPDE)
Healthy Controls: psychiatric Axis I disorder (SCID); BPD (IPDE)

Study & Design

Study Type: observational

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Cerebral activation pattern (BOLD) related to the processing of reward and the association of reward value with social stimuli. Change in activation pattern in the clinical samples should be linked to alterations in neuronal and behavioural correlates of mimicry measured during the test phase of the conditioning paradigm (paradigm 1) and paradigm 2 and 3

Secondary Outcome Measures

Name	Time	Method
Mimicry in test phase of paradigm 1, as well as in paradigm 2 and 3 measured by error rates, reaction times and EMG activity in response to emotional facial expression<br>Relation between alterations in the processing of reward, the association of reward to social stimuli and mimicry with social functioning (Social Functioning Scale, Birchwood et al. 1990) and psychopathological symptom severity (Borderline Symptomliste (Bohus et al., 2001), UCLA-Loneliness-Questionnaire (Russell et al. 1978).