Rehabilitation of Post-stroke Aphasia by a Single Protocol Targeting Phonological, Lexical, and Semantic Deficits With Speech Output Tasks: a Randomized Controlled Trial
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 44
- 主要终点
- Change from baseline in the auditory digit span
研究概览
简要总结
Aphasia in brain-damaged adult patients refers "to the more or less complete loss of the ability to use language" resulting from acquired brain damage, typically of the left hemisphere. The defective spoken output of persons with aphasia (PWA) has anomia as a main clinical manifestation. Improving anomia is a main goal of any language treatment.
The present randomized controlled study assessed the effectiveness of a novel, two-week, rehabilitation protocol (PHOLEXSEM), focused on PHonological, SEmantic, and LExical deficits, aiming at improving lexical retrieval, and, generally, spoken output.
The effects of the PHOLEXSEM treatment were compared to those of a control treatment, i.e., a Promoting Aphasics Communicative Effectiveness (PACE) protocol.
Finally, we studied the effects of age, education, disease duration, brain lesion volume, and functional independence (Functional Idependence Measure, FIM) on the treatment-induced linguistic improvements.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 90 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •acquired brain-damage
- •presence of aphasia
排除标准
- •global aphasia
- •undergoing another treatment for aphasia
结局指标
主要结局
Change from baseline in the auditory digit span
时间窗: At baseline and immediately after the intervention.
To assess auditory verbal short-term memory
Change from baseline in the Neuropsychological Examination of Language (ENPA)
时间窗: At baseline and immediately after the intervention.
A test for aphasia assessment in the Italian population
Change from baseline in phonemic fluency
时间窗: At baseline and immediately after the intervention.
To assess lexical retrieval based on a letter
Change from baseline in semantic fluency
时间窗: At baseline and immediately after the intervention.
To assess lexical retrieval based on a semantic category
Change from baseline in syntagma repetition
时间窗: At baseline and immediately after the intervention.
The syntagma repetition test from the Aachner Aphasie Test (AAT)
Change from baseline in the word repetition span
时间窗: At baseline and immediately after the intervention.
To assess auditory verbal short-term memory, with words stimuli
Change from baseline in the Token Test
时间窗: At baseline and immediately after the intervention.
To assess auditory language comprehension
次要结局
未报告次要终点