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Rehabilitation of Post-stroke Aphasia by Targeting Phonological, and Lexico-semantic Deficits With Speech Output Tasks

Not Applicable
Completed
Conditions
Stroke
Anomia
Aphasia, Acquired
Registration Number
NCT06451731
Lead Sponsor
Istituto Auxologico Italiano
Brief Summary

Aphasia in brain-damaged adult patients refers "to the more or less complete loss of the ability to use language" resulting from acquired brain damage, typically of the left hemisphere. The defective spoken output of persons with aphasia (PWA) has anomia as a main clinical manifestation. Improving anomia is a main goal of any language treatment.

The present randomized controlled study assessed the effectiveness of a novel, two-week, rehabilitation protocol (PHOLEXSEM), focused on PHonological, SEmantic, and LExical deficits, aiming at improving lexical retrieval, and, generally, spoken output.

The effects of the PHOLEXSEM treatment were compared to those of a control treatment, i.e., a Promoting Aphasics Communicative Effectiveness (PACE) protocol.

Finally, we studied the effects of age, education, disease duration, brain lesion volume, and functional independence (Functional Idependence Measure, FIM) on the treatment-induced linguistic improvements.

Detailed Description

Not available

Recruitment & Eligibility

Status
COMPLETED
Sex
All
Target Recruitment
44
Inclusion Criteria
  • acquired brain-damage
  • presence of aphasia
Exclusion Criteria
  • global aphasia
  • undergoing another treatment for aphasia

Study & Design

Study Type
INTERVENTIONAL
Study Design
PARALLEL
Primary Outcome Measures
NameTimeMethod
Change from baseline in the auditory digit spanAt baseline and immediately after the intervention.

To assess auditory verbal short-term memory

Change from baseline in the Neuropsychological Examination of Language (ENPA)At baseline and immediately after the intervention.

A test for aphasia assessment in the Italian population

Change from baseline in phonemic fluencyAt baseline and immediately after the intervention.

To assess lexical retrieval based on a letter

Change from baseline in semantic fluencyAt baseline and immediately after the intervention.

To assess lexical retrieval based on a semantic category

Change from baseline in syntagma repetitionAt baseline and immediately after the intervention.

The syntagma repetition test from the Aachner Aphasie Test (AAT)

Change from baseline in the word repetition spanAt baseline and immediately after the intervention.

To assess auditory verbal short-term memory, with words stimuli

Change from baseline in the Token TestAt baseline and immediately after the intervention.

To assess auditory language comprehension

Secondary Outcome Measures
NameTimeMethod

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