Rehabilitation of Post-stroke Aphasia by Targeting Phonological, and Lexico-semantic Deficits With Speech Output Tasks
- Conditions
- StrokeAnomiaAphasia, Acquired
- Registration Number
- NCT06451731
- Lead Sponsor
- Istituto Auxologico Italiano
- Brief Summary
Aphasia in brain-damaged adult patients refers "to the more or less complete loss of the ability to use language" resulting from acquired brain damage, typically of the left hemisphere. The defective spoken output of persons with aphasia (PWA) has anomia as a main clinical manifestation. Improving anomia is a main goal of any language treatment.
The present randomized controlled study assessed the effectiveness of a novel, two-week, rehabilitation protocol (PHOLEXSEM), focused on PHonological, SEmantic, and LExical deficits, aiming at improving lexical retrieval, and, generally, spoken output.
The effects of the PHOLEXSEM treatment were compared to those of a control treatment, i.e., a Promoting Aphasics Communicative Effectiveness (PACE) protocol.
Finally, we studied the effects of age, education, disease duration, brain lesion volume, and functional independence (Functional Idependence Measure, FIM) on the treatment-induced linguistic improvements.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 44
- acquired brain-damage
- presence of aphasia
- global aphasia
- undergoing another treatment for aphasia
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Primary Outcome Measures
Name Time Method Change from baseline in the auditory digit span At baseline and immediately after the intervention. To assess auditory verbal short-term memory
Change from baseline in the Neuropsychological Examination of Language (ENPA) At baseline and immediately after the intervention. A test for aphasia assessment in the Italian population
Change from baseline in phonemic fluency At baseline and immediately after the intervention. To assess lexical retrieval based on a letter
Change from baseline in semantic fluency At baseline and immediately after the intervention. To assess lexical retrieval based on a semantic category
Change from baseline in syntagma repetition At baseline and immediately after the intervention. The syntagma repetition test from the Aachner Aphasie Test (AAT)
Change from baseline in the word repetition span At baseline and immediately after the intervention. To assess auditory verbal short-term memory, with words stimuli
Change from baseline in the Token Test At baseline and immediately after the intervention. To assess auditory language comprehension
- Secondary Outcome Measures
Name Time Method