NCT00258232已完成2 期
Phase II Study of Celecoxib, Capecitabine, and Irinotecan in Patients With Metastatic Colorectal Cancer
适应症
相关药物
试验速览
- 阶段
- 2 期
- 状态
- 已完成
- 试验地点
- 6
- 主要终点
- Response rate by RECIST criteria at every other course
研究概览
简要总结
RATIONALE: Celecoxib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Drugs used in chemotherapy, such as capecitabine and irinotecan, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Giving celecoxib together with capecitabine and irinotecan may kill more tumor cells.
PURPOSE: This phase II trial is studying how well giving celecoxib together with capecitabine and irinotecan works in treating patients with recurrent or metastatic colorectal cancer.
详细描述
OBJECTIVES:
Primary
- Determine the objective response rate in patients with locally recurrent or metastatic colorectal cancer treated with celecoxib, capecitabine, and irinotecan.
Secondary
- Determine the time to progression in patients treated with this regimen.
- Determine the toxicity of this regimen in these patients.
- Determine the overall survival of patients treated with this regimen.
- Determine the time to treatment failure in patients treated with this regimen.
研究设计
- 研究类型
- Interventional
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- 未提供
排除标准
- 未提供
结局指标
主要结局
Response rate by RECIST criteria at every other course
次要结局
- Overall survival
- Time to treatment failure
- Time to progression
- Toxicity
研究者
研究点 (6)
Loading locations...
相似试验
终止
2 期
Neoadjuvant Celecoxib and Capecitabine Combined With Pelvic Irradiation in Treating Patients With Stage II or Stage III Adenocarcinoma (Cancer) of the RectumColorectal CancerNCT00081224Alliance for Clinical Trials in Oncology3
已完成
2 期
Celecoxib and Recombinant Interferon Alfa-2b in Metastatic Kidney Cancer Who Have Undergone SurgeryRenal Cell CancerStage IV Renal Cell CancerNCT01158534Case Comprehensive Cancer Center17
终止
2 期
Celecoxib and Docetaxel or Pemetrexed in Treating Patients With Advanced Recurrent Non-Small Cell Lung CancerLung CancerNCT00520845Vanderbilt-Ingram Cancer Center23
已完成
1 期
Celecoxib in Treating Patients With Stage IIIB or Stage IV Non-Small Cell Lung CancerLung CancerNCT00104767Jonsson Comprehensive Cancer Center7
撤回
1 期
Celecoxib and Erlotinib in Treating Patients With Liver CancerLiver CancerNCT00293436University of California, San Francisco