Effects of a butyrate enema on systemic concentrations of short chain fatty acids

Recruiting

• Conditions: livermetastasis; pancreascarcinoma; 10017934; 10019654

• Registration Number: NL-OMON32250
• Lead Sponsor: niversiteit Maastricht

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 13 May 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: Not specified
• Target Recruitment: 20

Inclusion Criteria

• Patients undergoing major upper abdominal surgery, i.e. partial hepatectomy or pylorus preserving pancreactico duodenectomy.
• Normal liver function, i.e. AST within normal range
• Stable western diet
• Age > 18 years old
• Written informed consent

Exclusion Criteria

• Ileo- or colostomy
• Parenchymal or inflammatory liver disease
• Steroid hormone medication
• Lactation, pregnancy
• Inflammatory bowel disease
• Inborn errors of metabolism (liver enzyme deficiencies)
• Excessive drinking (>20 alcoholic consumptions per week)
• Smoking
• Use of antibiotics during and 3 months prior to the study
• Probiotic use during and 2 weeks prior to the study

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>short chain fatty acid concentrations in portal, mesenteric, arterial and<br /><br>hepatic venous blood. From these data we can calculate the role of the liver,<br /><br>large and small intestine and the spleen in SCFA metabolism.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>nvt</p><br>