Optimization of PEEP for Alveolar Recruitment in ARDS
Completed
- Conditions
- ARDS
- Registration Number
- NCT01949272
- Lead Sponsor
- Hopital of Melun
- Brief Summary
Actual setting of PEEP in ARDS is based on tables linked to FiO2, or respiratory system plateau pressure (e.g EXPRESS Study) or set regarding esophageal pressure mesurement and transpulmonary pressure calculation. Opera study should confirm if a setting approach based on esophageal pressure is helpfull for any ARDS patient in ICU without deleterious side-effect.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 22
Inclusion Criteria
- ARDS Stades 2 and 3 with invasive ventilation (EXPRESS settings) within 3 to 12 hours
Exclusion Criteria
- less 18 years, pregnancy, intracardiac shunt, esophageal catheter cons-indicated
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method PaO2/FiO2 ratio 24 hours
- Secondary Outcome Measures
Name Time Method Vd/Vt ratio 24 hours
Related Research Topics
Explore scientific publications, clinical data analysis, treatment approaches, and expert-compiled information related to the mechanisms and outcomes of this trial. Click any topic for comprehensive research insights.
What molecular mechanisms underlie alveolar recruitment in ARDS patients using esophageal pressure measurement?
How does PEEP optimization based on transpulmonary pressure compare to standard FiO2-based methods in ARDS management?
Are there specific biomarkers that correlate with improved outcomes in ARDS patients undergoing esophageal pressure-guided PEEP adjustments?
What adverse events are associated with esophageal pressure monitoring in ICU ARDS patients and how are they managed?
How does the Opera study's PEEP strategy compare to other ARDS ventilatory approaches like prone positioning or neuromuscular blockade?
Trial Locations
- Locations (1)
Melun Hospital ICU
🇫🇷Melun, France
Melun Hospital ICU🇫🇷Melun, France