Epimorph COVID Acute Respiratory Distress Syndrome
Not Applicable
- Conditions
- Health Condition 1: B972- Coronavirus as the cause of diseases classified elsewhere
- Registration Number
- CTRI/2021/07/035093
- Lead Sponsor
- Swagata Tripathy
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Open to Recruitment
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
COVID 19 ARDS patients on NIV, P/F Ration < 300 with High respiratory Drive- TFDi > 30% ( secondary - Vt > 10 ml/ kg. RR > 25 /min )
Exclusion Criteria
Metabolic acidosis HCO3- < 16 or pH < 7.2. Severe hypoxemia warranting cessation of NIV and intubation, non-acceptance of NIV. Technical difficulty for epidural catheterization, coagulation abnormalities, low respiratory drive, EOL orders, chronic opioid use.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Diaphragm thickening index fractionTimepoint: Average of 3 readings at 3 time points each 24 hours, for the duration of minimum 48 hours and a maximum of 100 hours
- Secondary Outcome Measures
Name Time Method Ventilatory parameters, sedation and pain scores, subjective comfort and dyspnoea scores, time to intubation, length of stay on NIV, 28 day mortality.Timepoint: Average of 3 readings at 3 time points each 24 hours, for the duration of minimum 48 hours and a maximum of 100 hours