Study the Effect of Blood Transfusion on Oxidant-antioxidant Status in Term and Near-term Neonates
- Conditions
- Blood Transfusion ComplicationOxidative Stress
- Registration Number
- NCT03767361
- Lead Sponsor
- Rania Ali El-Farrash
- Brief Summary
Primary aim is to evaluate the effect of blood transfusion on oxidant-antioxidant status in premature neonates. Secondary aim is to assess the effect of the age of transfused red blood cells on the biological markers of oxidative stress.
- Detailed Description
Oxidant-antioxidant status will be assessed by measuring total antioxidant capacity (TAC) and malondialdehyde (MDA), as well as antioxidant minerals, in 65 term and near-term neonates.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 65
- Premature neonates ≤36 weeks in need for blood transfusion.
- Critically ill neonates.(perinatal asphaxia,on high setting mechanical ventilation,different types of shock eg ;septic shock and major congenital anomalies)
- Extremely low birth weight neonates(<1000gm birth weight )
- Recipient of blood transfusion before enrollment in the study.
- Neonates planned for exchange transfusion .
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Primary Outcome Measures
Name Time Method total antioxidant capacity 2-3 hours posttransfusion TAC
serum Copper 2-3 hours posttransfusion s.Cu
serum iron 2-3 hours posttransfusion s.Fe
serum Calcium 2-3 hours posttransfusion s.Ca
serum Zinc 2-3 hours posttransfusion s.Zn
malondialdehyde 2-3 hours posttransfusion MDA
serum magnesium 2-3 hours posttransfusion s.Mg
- Secondary Outcome Measures
Name Time Method
Related Research Topics
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Trial Locations
- Locations (1)
Rania Farrash
🇪🇬Cairo, Egypt
Rania Farrash🇪🇬Cairo, Egypt