Study the Effect of Blood Transfusion on Oxidant-antioxidant Status in Term and Near-term Neonates
Early Phase 1
Completed
- Conditions
- Blood Transfusion ComplicationOxidative Stress
- Registration Number
- NCT03767361
- Lead Sponsor
- Rania Ali El-Farrash
- Brief Summary
Primary aim is to evaluate the effect of blood transfusion on oxidant-antioxidant status in premature neonates. Secondary aim is to assess the effect of the age of transfused red blood cells on the biological markers of oxidative stress.
- Detailed Description
Oxidant-antioxidant status will be assessed by measuring total antioxidant capacity (TAC) and malondialdehyde (MDA), as well as antioxidant minerals, in 65 term and near-term neonates.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 65
Inclusion Criteria
- Premature neonates ≤36 weeks in need for blood transfusion.
Exclusion Criteria
- Critically ill neonates.(perinatal asphaxia,on high setting mechanical ventilation,different types of shock eg ;septic shock and major congenital anomalies)
- Extremely low birth weight neonates(<1000gm birth weight )
- Recipient of blood transfusion before enrollment in the study.
- Neonates planned for exchange transfusion .
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Primary Outcome Measures
Name Time Method total antioxidant capacity 2-3 hours posttransfusion TAC
serum Copper 2-3 hours posttransfusion s.Cu
serum iron 2-3 hours posttransfusion s.Fe
serum Calcium 2-3 hours posttransfusion s.Ca
serum Zinc 2-3 hours posttransfusion s.Zn
malondialdehyde 2-3 hours posttransfusion MDA
serum magnesium 2-3 hours posttransfusion s.Mg
- Secondary Outcome Measures
Name Time Method
Related Research Topics
Explore scientific publications, clinical data analysis, treatment approaches, and expert-compiled information related to the mechanisms and outcomes of this trial. Click any topic for comprehensive research insights.
How does packed red blood cell transfusion impact total antioxidant capacity (TAC) and malondialdehyde (MDA) in term/near-term neonates?
What molecular pathways link blood transfusion to oxidative stress in neonatal patients with transfusion complications?
Do antioxidant minerals like selenium or zinc correlate with reduced oxidative stress biomarkers post-transfusion in neonates?
How does red blood cell storage duration affect oxidative stress markers in transfused term and near-term infants?
What strategies mitigate transfusion-induced oxidative stress in neonates using antioxidant supplementation or alternative therapies?
Trial Locations
- Locations (1)
Rania Farrash
🇪🇬Cairo, Egypt
Rania Farrash🇪🇬Cairo, Egypt