Femoral/Sciatic Block for Knee Surgery

Not Applicable

Completed

• Conditions: Knee Injuries
• Interventions: Procedure: femoral nerve blockade; Procedure: morphine

• Registration Number: NCT02882152
• Lead Sponsor: University of Sao Paulo General Hospital

Brief Summary

Knee arthroplasty has a high potential for postoperative pain. This study compares analgesia and postoperative bleeding from intrathecal morphine with the continuous femoral and a single-shot sciatic nerve blockades.

Detailed Description

This study aims to compare intrathecal morphine as a technique for analgesia with the femoral nerve blockade associated with a single-shot sciatic nerve blockade. Analgesic efficacy, the incidence of adverse effects, and postoperative bleeding were evaluated

Study Timeline

• Study Start: 2011-08
• Status Verified: 2014-09
• Primary Completion: 2014-09
• Study Completion: 2014-09
• Study First Submitted: 2016-08-24
• Study First Submitted QC: 2016-08-26
• Study First Posted: 2016-08-29
• Results First Submitted: 2016-09-06
• Results First Submitted QC: 2016-12-23
• Last Update Submitted: 2016-12-23
• Results First Posted: 2016-12-26
• Last Update Posted: 2016-12-26

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

• Patients aged over 18 years old, American Society of Anesthesiologists (ASA) physical status from I to III who underwent total knee arthroplasty

Exclusion Criteria

• Patients aged below 18 years old, ASA IV or V physical status, infection near the puncture site, coagulation disorders, preexisting neurological disorders, allergy report to local anesthetics, pregnancy and lactation, contraindications to spinal block and refusal to sign an informed consent form

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
femoral blockade	femoral nerve blockade	femoral nerve blockade followed by a catheter placement for continuous infusion and a "single shot" block of the sciatic nerve
Morphine	morphine	intrathecal morphine

Primary Outcome Measures

Name	Time	Method
Analgesic Efficacy	baseline (zero hour: discharge of post-anesthesia care unit-PACU), 24hs, 48hs, 72 hours	Pain with verbal numeric rating scale (VNRS). VNRS has 11 points, from zero to 10 (zero= no pain, 1-3 = mild pain, 4-5 = moderate pain, 7-9 = severe pain, 10 = unbearable pain).

Secondary Outcome Measures

Name	Time	Method
Postoperative Bleeding	baseline (discharge of post-anesthesia care unit-PACU), 24hs, 48hs, 72 hours	Postoperative bleeding volume (ml)