Diaphragm electromyography to estimate breathing effort and fatigue : a physiological study

Completed

Conditions: Intensive Care zorg
Respiratory muscle dysfunction
Weakness of the muscles of breathing
10028302
10013369

Registration Number: NL-OMON46673

Lead Sponsor: Vrije Universiteit Medisch Centrum

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 23

Inclusion Criteria

Informed consent
Age *18 years

Exclusion Criteria

History of cardiac and/or pulmonary disease
Current cardiac and/or pulmonary symptoms
History of pneumothorax
Contradinication for nasogastric tube placement (recent epistaxis, upper airway surgery, coagulopathy)

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>1) To create a model that predicts the relationship between Electrical activity<br /><br>of the diaphragm (uV) andTrans-diaphragmatic pressure (Pdi), calculated as<br /><br>Stomach pressure (Pga) - Esophageal pressure (Pes).<br /><br><br /><br>2) Investigate how accurate the predicted Pdi is when calculating the<br /><br>pressure-time product (PTP) and the breath work (WOB) </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>1) Investigate to what extent the predicted Pdi values are accurate during<br /><br>fatiguing loads.<br /><br>2) Examine to what extent and in what order the accessory and expiratory<br /><br>respiratory muscles are recruited during increased work of breathing. </p><br>