Comparison of Topically Applied Ozonated Gel and Titanium Platelet-rich Fibrin (Tprf) on Palatal Wound Healing (A Randomized Controlled Clinical Trial)
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 39
- 试验地点
- 1
- 主要终点
- Change in pain scores
研究概览
简要总结
Background: autogenous soft tissue grafts can be considered the gold standard for treatment of mucogingival problems. The most common site for harvesting the graft is the palate. The palatal donor site for free gingival graft (FGG) significantly influences the pain and discomfort experienced by the patient, and there is a potential for postoperative bleeding.To overcome these problems many dressing materials associated with topical formulae have been used.
Aim: The objective of this study is to assess the effect of topically applied ozonated oil on palatal wound healing and compare it to the effect of titanium platelet rich fibrin (TPRF)
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 20 Years 至 50 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Isolated gingival recession defects on the mandibular and maxillary anterior teeth with insufficient keratinized gingiva.
- •Good oral hygiene
排除标准
- •Patients reporting systemic conditions that may compromise healing or bone metabolism
- •Patients having a history of radiotherapy, chemotherapy or bisphosphonate therapy.
- •Pregnant women or those planning to get pregnant during the study course
- •History of periodontal disease or previous periodontal surgery on the experimental sites
- •Smoking or any other deleterious habits.
研究组 & 干预措施
ozonated gel
干预措施: Ozonated Gel Application (Other)
Application of TPRF
干预措施: T-PRF Application (Other)
flowable composite
干预措施: Conventional treatment (Other)
结局指标
主要结局
Change in pain scores
时间窗: Up to 14 days
Patients will be asked to grade the severity of pain using VAS. It ranges across a continuum from none to an extreme amount of pain in a straight horizontal 10 cm line \[from 0-100 mm\].
Change in wound area
时间窗: Baseline, 3 days, 7 days, 10 days, and 14 days
Standardized clinical photographs of the palatal surgical sites will be obtained on the day of surgery and at 3, 7, 10, and 14 days postoperatively. Photographs will be taken perpendicular to the wound area, with a standard-sized visual scale placed adjacent to the palatal wounds to allow accurate wound size measurement and analysis.
次要结局
未报告次要终点