on-osmotic sodium storage in placental tissue in hypertensive and normotensive pregnancies

Recruiting

• Conditions: high blood pressure in pregnancy; Hypertensive disorder of pregnancy; 10035129

• Registration Number: NL-OMON48312
• Lead Sponsor: Academisch Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 11 June 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: Not specified
• Target Recruitment: 150

Inclusion Criteria

- Pregnant women aged >= 18 years with a hypertensive disorder of pregnancy (pre-eclampsia, HELLP syndrome, gestational hypertension, chronic hypertension in pregnancy)
- Gestational age between 28 weeks to 40 0/7 weeks;
- Healthy subjects should be aged >= 18 years, normotensive during the whole pregnancy and matched for gestational age.

Exclusion Criteria

- Pregnant women aged <18 years;
- Pregnant women with multiple pregnancies;
- Diagnosis of end stage renal disease;
- Medical history of diabetic disease;
- Presence of a known congenital anomaly;
- Presence of congenital infections;
- Unwillingness to participate in the study or to cede the placenta after delivery.

Study & Design

• Study Type: Observational non invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The chief parameter we will be studying is the difference in the amount of<br /><br>non-osmotic sodium storage in placental tissue, defined as sodium content per<br /><br>dry weight, between placentas of hypertensive pregnancies and normotensive<br /><br>pregnancies. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>• The distribution of non-osmotic sodium storage in placental tissue;<br /><br>• The difference in GAG expression.</p><br>