on-osmotic sodium storage in placental tissue in hypertensive and normotensive pregnancies
- Conditions
- - Pregnancy induced hypertension- Chronic hypertension in pregnancy- Early-onset pre-eclampsia - Late-onset pre-eclampsia
- Registration Number
- NL-OMON27314
- Lead Sponsor
- Amsterdam UMC – location AMC
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- Not specified
- Target Recruitment
- 150
Inclusion Criteria
Aged 18 years or above;
- Uncomplicated pregnancy or hypertensive disorder of pregnancy defined as: pregnancy induced hypertension, chronic hypertension in pregnancy, early-onset pre-eclampsia or late-onset pre-eclampsia;
- Gestational age between 28 weeks to 40 0/7 weeks.
Exclusion Criteria
- Pregnant women aged <18 years;
- Pregnant women with multiple pregnancies;
- Diagnosis of end stage renal disease;
- Medical history of diabetic disease;
- Presence of a known congenital anomaly;
- Presence of congenital infections;
- Unwillingness to participate in the study or to cede the placenta after delivery.
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Differences in the amount of non-osmotic sodium storage in placental tissue between hypertensive pregnancies (including chronic hypertension, gestational hypertension, late-onset and early-onset pre-eclampsia) and normotensive pregnancies.
- Secondary Outcome Measures
Name Time Method - Differences in the distribution of non-osmotic sodium storage in placental tissue; <br>- Differences in the expression of GAGs in placental tissue between hypertensive and normotensive pregnancies.