Short- and Long-term Reproducibility of Dual Beam Doppler Fourier-domain Optical Coherence Tomography Measurements in Healthy Subjects - a Pilot Study
Trial Snapshot
- Phase
- Not Applicable
- Status
- Recruiting
- Sponsor
- Medical University of Vienna
- Enrollment
- 20
- Locations
- 2
- Primary Endpoint
- Retinal blood-flow variation over time
Study Overview
Brief Summary
Dual beam Doppler Fourier-domain Optical coherence tomography (DOCT) is a noninvasive technique to quantify total retinal blood flow.
To enable further development of this technique it is essential to assess short- and long-term reproducibility of DOCT blood flow measurements.
Detailed Description
In the present study, total retinal blood flow will be measured with DOCT at multiple time points to gain information of short- and long-term reproducibility. In addition, provocation with flickering light will be performed, which is known to lead to vasodilatation and an increase in retinal blood flow in healthy subjects. Vessel diameters will also be measured using the Dynamic Vessel Analyzer (DVA).
Study Design
- Study Type
- Interventional
- Allocation
- Na
- Intervention Model
- Single Group
- Primary Purpose
- Basic Science
- Masking
- None
Eligibility Criteria
- Ages
- 18 Years to 35 Years (Adult)
- Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •Men and women aged between 18 and 35 years
- •Non-smokers
- •Normal findings in the medical history unless the investigator considers an abnormality to be clinically irrelevant
- •Normal ophthalmic findings, ametropy < 3 Dpt.
Exclusion Criteria
- •Regular use of medication, abuse of alcoholic beverages, participation in a clinical trial in the 3 weeks preceding the study
- •Treatment in the previous 3 weeks with any drug (except contraceptives)
- •Symptoms of a clinically relevant illness in the 3 weeks before the first study day
- •Blood donation during the previous 3 weeks
- •Pregnancy, planned pregnancy or lactating
- •History or family history of epilepsia
Outcomes
Primary Outcomes
Retinal blood-flow variation over time
Time Frame: 14 +/- 3 days
as measured using DOCT
Secondary Outcomes
- Flicker induced blood flow alterations(14 +/- 3 days)
- Flicker induced vasodilatation and hyperemia(14 +/- 3 days)
Investigators
Doreen Schmidl
Associate Professor, MD, PhD
Medical University of Vienna