Optical Coherence Tomography-Aided Differential Diagnosis and Treatment of Irregular Corneas
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Keratoconus
- Sponsor
- Oregon Health and Science University
- Enrollment
- 445
- Locations
- 1
- Primary Endpoint
- Develop OCT metrics for more sensitive detection of keratoconus progression
- Status
- Recruiting
- Last Updated
- 7 months ago
Overview
Brief Summary
This main goal of this study is to improve the detection, classification, monitoring, and treatment of irregular corneas due to keratoconus, warpage, dry eye, scar, stromal dystrophies, and other corneal conditions.
The primary goal will be achieved by using optical coherence tomography (OCT) to:
- Develop an OCT-based system to classify and evaluate corneal-shape irregularities.
- Develop OCT metrics for more sensitive detection of keratoconus progression.
- Develop OCT-and-topography guided phototherapeutic keratectomy (PTK) for irregular corneas.
Investigators
David Huang
Yan Li, PhD, Assistant Professor of Ophthalmology
Oregon Health and Science University
Eligibility Criteria
Inclusion Criteria
- •Keratoconus:
- •CDVA ≥ 20/25 in the better eye; and both of the following in the worse eye
- •Topography characteristic of keratoconus or pellucid marginal degeneration
- •Contact lens-related corneal warpage:
- •Contact lens use; and
- •Topography irregularities
- •Symptoms of dry eye documented by Ocular Surface Disease Index (OSDI) questionnaire score ≥ 30; and
- •Topography irregularities
- •Presence of punctate epithelial erosion on exam with surface staining
- •Aqueous deficiency or evaporative dry eye
Exclusion Criteria
- Not provided
Outcomes
Primary Outcomes
Develop OCT metrics for more sensitive detection of keratoconus progression
Time Frame: 4 year
Secondary measurement will be OCT corneal shape assessed in Diopter units.
Develop OCT- and topography-guided phototherapeutic keratectomy (PTK) for irregular corneas
Time Frame: 1 year
The secondary goal is to improve the post-procedural outcome of refractive error. This will be measured in Diopter units.
Develop OCT-based system to classify and evaluate corneal-shape irregularities
Time Frame: 1 day
Secondary measurement will be OCT corneal shape assessed in Diopter units.