Vitamin D and depressio
Early Phase 1
- Conditions
- depression.Major depressive disorder, single episode, unspecified
- Registration Number
- IRCT20170926036425N1
- Lead Sponsor
- ational Nutrition and Food Technology Researc Institute
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 60
Inclusion Criteria
having mild to moderate depression
age: 18 to 60 y
Exclusion Criteria
having a history of heart infarction
having a history of angina
having a history of stroke
having a history of kidney stones
having a history of high blood pressure (systolic blood pressure higher than 174 or diastolic blood pressure higher than 104 mm Hg)
having a history of liver disease
having a history of hyperparathyroidism
pregnancy and/or lactation
Reproductive-aged women (under 50 years old) who are not receiving adequate contraception
consuming nutritional supplement containing vitamin D from 2 months ago
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Serum 25(OH)D concentration. Timepoint: baseline and 8 weeks after intervention. Method of measurement: measurement of serum level of 25OHD.
- Secondary Outcome Measures
Name Time Method Proinflammatory biomarkers. Timepoint: baseline and 8 weeks after intervention. Method of measurement: measurement of serum hs-CRP, IL-6, IL-1ß concentrations.;Bone biomarker. Timepoint: baseline and 8 weeks after intervention. Method of measurement: measurement of serum parathormone concentration.;Some neurotransmitters involved in depression. Timepoint: baseline and 8 weeks after intervention. Method of measurement: measurement of serum oxytocin and platelet serotonin concentrations.;Depression status. Timepoint: baseline and 8 weeks after intervention. Method of measurement: Using Beck questioner.