Effect of Barley Supplemented Wheat Bread on Markers of Cardiovascular and Renal Health: A Randomized Controlled Trial
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 25
- 试验地点
- 2
- 主要终点
- Change in Serum Nitric oxide from baseline to 4 weeks
研究概览
简要总结
The disruption of colonic microbiota has been linked to a number of diseases, mainly cardiovascular and kidney diseases. One possible means to improve the microbiota is to increase dietary fiber intake as the intake of dietary fiber shifts the fermentation from proteolytic saccharolytic fermentation.
Beta-glucans are soluble dietary fibers mainly found in oats and barley. Results from previous studies suggest that the consumption of barley reduces the risk of cardiovascular and kidney diseases. Therefore, this study will explore the effect of barley beta-glucans on markers of Cardiovascular and Renal health.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Healthy individuals of age 18 years or older
- •BMI ranged between 18.5 and 24.9
排除标准
- •Celiac disease, Cancer, Diabetes , cardiovascular diseases
- •Gastro intestinal tract disease
- •Pregnant women
- •Use of pre-, pro- or antibiotics 15 days before the enrollment into the study
- •Food allergy to food used in the trial
结局指标
主要结局
Change in Serum Nitric oxide from baseline to 4 weeks
时间窗: Baseline and after 4 weeks
change in Serum E-selectin from baseline to 4 weeks
时间窗: Baseline and after 4 weeks
Change in Serum P-cresyl sulfate from baseline to 4 weeks
时间窗: Baseline and after 4 weeks
Change in Serum Thiobarbituric acid reactive substances (TBARs) from baseline to 4 weeks
时间窗: Baseline and after 4 weeks
Change in Serum Total antioxidant capacity (TAC) from baseline to 4 weeks
时间窗: Baseline and after 4 weeks
Change in Serum Indoxyl sulfate from baseline to 4 weeks
时间窗: Baseline and after 4 weeks
次要结局
未报告次要终点
研究者
Bibi Hajira
Assistant Professor
Khyber Medical University Peshawar