The Becoming of Children With Doose Syndrome

Recruiting

• Conditions: Learning Disabilities; Doose Syndrome; Epileptic Syndromes

• Registration Number: NCT04048213
• Lead Sponsor: Centre Hospitalier Universitaire, Amiens

Brief Summary

Doose syndrome is a rare epileptic syndrome that can lead to learning difficulties and a poor quality of life. The goal of this study is to evaluate the evolution of epilepsy and its consequences on cognitive development and learning issues in children with Doose syndrome.

Detailed Description

Doose syndrome is a rare epileptic syndrome beginning between ages two and five, characterized by myoclonic-astatic seizures which can be associated with myoclonic seizures, astatic seizures, absences and generalized tonic-clonic seizures. These seizures can be difficult to treat effectively and may lead to learning difficulties. During this study, parents of children with Doose syndrome will receive a questionnaire regarding learning disabilities, quality of life and epilepsy of their children.

Study Timeline

• Study Start: 2019-08-01
• Study First Submitted: 2019-08-06
• Study First Submitted QC: 2019-08-06
• Study First Posted: 2019-08-07
• Status Verified: 2023-04
• Last Update Submitted: 2023-04-11
• Last Update Posted: 2023-04-12
• Primary Completion: 2023-12
• Study Completion: 2023-12

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 50

Inclusion Criteria

• children with doose syndrome diagnosed between ages 1 and 6
• normal development until onset of seizures

Exclusion Criteria

• unconfirmed diagnoses
• abnormal diagnoses
• abnormal psychomotor development before onset of seizures
• cerebral MRI abnormalities
• other child epileptic syndromes

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
disease effects on the learning ability of children with doose syndrome	day of inclusion	disease effects on the learning ability of children with doose syndrome base on scholar informations

Secondary Outcome Measures

Name	Time	Method
Evolution of epilepsy in children with doose syndrome based on pathological symptoms	day of inclusion	Evolution of epilepsy in children with doose syndrome based on pathological symptoms

Trial Locations

Locations (1)

CHU Amiens; 🇫🇷 Amiens, France