Clinical Relevance of Intracellular Staphylococci in BOne and Joint Infections

Completed

• Conditions: Bone and Joint Infection; Staphylococcus
• Interventions: Other: Patients having had an osteo-articular infection with Stahylococcus

• Registration Number: NCT04625478
• Lead Sponsor: Hospices Civils de Lyon

Brief Summary

Different mechanisms have been proposed to explain the pathophysiology of chronic staphylococcal BJI, including biofilm formation and the ability of staphylococci to be internalized and to survive within cells. The intracellular localization of staphylococci is well documented by in vitro studies, however, few studies have shown the presence of intracellular staphylococci in clinical specimens from patients with BJI.

The aim of the CRISBO study is to document the clinical relevance of intracellular staphylococci in the context of BJI. Immunostaining targeting staphylococci and components will be carried out on tissue samples taken from patients with BJI during their treatment (samples similar to those used for routine diagnosis in pathology). Our objectives are to identify whether intracellular staphylococci are observable in these samples and if so, in which cell type (s) are they housed.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2020-11-06
• Study First Submitted QC: 2020-11-06
• Study First Posted: 2020-11-12
• Study Start: 2020-12-01
• Primary Completion: 2021-09-20
• Study Completion: 2021-12-20
• Status Verified: 2022-01
• Last Update Submitted: 2022-01-11
• Last Update Posted: 2022-01-12

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 50

Inclusion Criteria

• patients having had an osteo-articular infection with Staphylococci

Read More

Exclusion Criteria

Read More

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Patients having had an osteo-articular infection with Stahylococcus	Patients having had an osteo-articular infection with Stahylococcus	Patients having had an osteo-articular infection with Stahylococcus managed at the Croix Rousse hospital

Primary Outcome Measures

Name	Time	Method
detection of intracellular staphylococci	2 months	to explore if intracellular staphylococci can be observed on samples of patient having an osteo-articular infection with staphylococci
rate of localisation of intracellular staphylococci	2 months	to explore where in what type of celles they can be observed on samples of patient having an osteo-articular infection with staphylococci

Trial Locations

Locations (1)

Hospices Civils de Lyon; 🇫🇷 Lyon, France