CanScan; Community-based Registry to Assess, Address and advaNce SCreening for cANcer Prevention and Management
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 10,000
- 试验地点
- 2
- 主要终点
- Rate of Pathogenic Germline Variants (PGV)
研究概览
简要总结
Early diagnosis of cancer allows for better treatment outcomes, higher survival rates, and lower costs of care. It is shown that cancer monitoring for cancer in at-risk populations is a key component in early diagnosis. The HMH Hennessey Institute for Cancer prevention and Applied Molecular Science (HICAP) is a newly founded institute, providing clinical services for cancer screening and risk assessment to the community, as well as research in cancer risk and prevention. The CanScan registry will prospectively collect data from participants in the form of questionnaires. The registry will also capture data that is collected as per non-research assessments, for participants who consent to participate. The registry will facilitate better understanding of cancer risk, screening, and diagnostics.
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Adults ( 18 and older)
- •Ability to provide own consent
- •Must meet at least one of the below criteria, Indicating an increased risk for cancer, any of the following:
- •Family or personal history suggests a familial/hereditary disorder known or suspected of predisposition to cancer.
- •Personal factors associated with an increased risk for cancer include benign breast disease, polyps, tobacco use, etc.as defined by the investigator.
- •Family members of participating individuals.
- •Any participant in the HICAP program regardless of cancer risk
排除标准
- 未提供
结局指标
主要结局
Rate of Pathogenic Germline Variants (PGV)
时间窗: 10 years from study initiation as defined based on the date the first patient was enrolled.
Compare the number of detected PGVs as measured by a universal multi-gene panel, proactively, in a diverse community-based population of individuals. PGV rate will be compared to NCCN genetic testing criteria at baseline, and to longitudinal cancer outcomes.
次要结局
- Incidence of Cancer(10 years from study enrollment.)
- Genetic Risk Score (GRS)(10 years from study enrollment)
- Environmental and Lifestyle Factors(10 years from study enrollment)
- Impact of Early Detection and Prevention on Cancer Outcomes(10 years from study enrollment)