The role of sex hormones in the provocation of migraine attacks in female migraine patients
- Conditions
- Migraine10019231
- Registration Number
- NL-OMON52784
- Lead Sponsor
- eids Universitair Medisch Centrum
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 132
- Women aged >= 18 years
- Menstrual migraine OR Early menopausal transition phase
- Migraine frequency: >= 1 attack/month
- Regular menstrual cycle with a cycle length between 25-32 days OR LH surge
between days 5 and 25 of the menstrual cycle
- Normal, mildly increased or decreased BMI
- Insufficient mastery of Dutch
- Inability to complete the electronic diary in an accurate manner
- Smoking
- Chronic migraine
- Medication-overuse headache (ICHD-3 criteria)
- Women who are breastfeeding, pregnant, or planning to become pregnant
- Oral contraceptive use during the last month and not willing to undergo
washout period (stop for one month)
- Other sex hormone containing treatment use during the last month
- Use of corticosteroids during the last month
- Anamnestic signs of anemia
- Any serious illness that can compromise study participation
- Freezer of insufficient quality
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>Serum levels of estradiol during days 8, 10, 12 and 14 after the LH surge</p><br>
- Secondary Outcome Measures
Name Time Method <p>Serum levels of progesterone during days 8, 10, 12 and 14 after the LH surge<br /><br>Serum levels of estradiol and progesterone during days 1, 2 and 3 after the LH<br /><br>surge<br /><br>Serum levels of 17-hydroxyprogesterone, testosterone, dihydrotestosterone,<br /><br>androstenedione, DHEA, DHEAS, SHBG, LH, FSH and CGRP during days 1, 2, 3, 8,<br /><br>10, 12 and 14 after the LH surge.</p><br>