Vitamin D in non-allergic asthma.
Recruiting
- Conditions
- on-atopic asthmaNiet-atopisch asthma
- Registration Number
- NL-OMON20565
- Lead Sponsor
- Medical Centre Leeuwarden
- Brief Summary
/A
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 48
Inclusion Criteria
1. Outpatients with non-atopic asthma, determined by negative alatop;
2. Pulmonologist's diagnosis of asthma;
Exclusion Criteria
1. Patients with smoking history of >10 packyears and persistent airflow obstruction (postbronchodilator FEV1<80%pred): Excluded if reversibility in FEV1 <12% predicted OR TLCO<80%pred;
2. Pregnancy;
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The change in percentage of neutrophils and/or eosinophils in induced sputum before and 8-10 weeks after vitamin D administration.
- Secondary Outcome Measures
Name Time Method 1. Extent of sinus disease as measured on CT-sinus;<br /><br>2. Levels of FEV1 and exhaled NO;<br /><br>3. Quality of life, Asthma control an SNOT-questionnaire. <br><br /><br /><br>Measurements will take place before and 8-10 weeks after vitamin D administration. Adverse events will be compared between the intervention group and placebo. Baseline characteristics will be used to identify potentials predictors of response.