An evaluation of the blood thinning effects of the medications Alteplase and Dornase in the management of adults with complex pleural infections.

Not Applicable

Not yet recruiting

• Conditions: Pleural infection; Respiratory - Other respiratory disorders / diseases; Blood - Clotting disorders; Infection - Other infectious diseases

• Registration Number: ACTRN12623000169640
• Lead Sponsor: orthern Health

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2023-02-17
• Last Update Posted: 27 February 2023

Recruitment & Eligibility

• Status: Not yet recruiting
• Sex: All
• Target Recruitment: 50

Inclusion Criteria

Adult patients (18 years and older) with complex pleural infections requiring intrapleural tPA and DNAse as decided by their treating physician.
Complex pleural infection are those infections that do not resolve/drain with antibiotics and thorocostomy tube that may have a loculated/septated appearance on imaging, may have a purulent macroscopic appearance and may have cultured bacteria from pleural fluid.

Exclusion Criteria

Individuals that are deemed unsuitable for intrapleural tPA. These include those with active bleeding, current use of an anticoagulant with evidence of affected coagulation status, a medical condition which results in an affected coagulation status or those that are pregnant.

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Change in serum coagulation assays following the administration of intrapleural tPA. Specifically change in International Normalised Ratio (INR),[45 minutes following first dose of intrapleural tPA<br>45 minutes following second dose of intrapleural tPA<br>45 minutes following third (final) of intrapleural tPA];Change in serum coagulation assays following the administration of intrapleural tPA. <br>Specifically change in Activated Partial Thromboplastin Time (APTT)[45 minutes following first dose of intrapleural tPA<br>45 minutes following second dose of intrapleural tPA<br>45 minutes following third (final) of intrapleural tPA];Change in serum coagulation assays following the administration of intrapleural tPA. <br>Specifically change in fibrinogen.[45 minutes following first dose of intrapleural tPA<br>45 minutes following second dose of intrapleural tPA<br>45 minutes following third (final) of intrapleural tPA]