Impact of Perioperative Shedding of the Endothelial Glycocalyx on Short-term Postoperative Complication in Patients Undergoing Robot-assisted Esophagectomy
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 221
- 试验地点
- 1
- 主要终点
- blood concentration of syndecan-1 at 24 hours after surgery
研究概览
简要总结
The aim of this study was to determine whether changes in serum levels of syndecan-1 before and after surgery, which is an index related to injury of the endothelial glycocalyx layer, are associated with postoperative short-term complications and mortality in patients undergoing robotic esophagectomy.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 20 Years 至 —（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •patients 20 years or older who undergo robotic esophagectomy
排除标准
- •Emergency surgery
- •If the subject includes a person who can not read the written consent (eg, illiterate, foreigner, etc.)
- •Chronic kidney disease (eGFR <30 mL / min / 1.73 m2)
- •Pregnant and lactating women
- •Use of oral anticoagulants
结局指标
主要结局
blood concentration of syndecan-1 at 24 hours after surgery
时间窗: 24 hours after the end of surgery
blood concentration of syndecan-1 at 24 hours after surgery
base blood concentration of syndecan-1
时间窗: within 1 hour before surgery
preoperative baseline serum levels of syndecan-1
blood concentration of syndecan-1 at the end of the surgery
时间窗: within 5 minutes after the end of surgery (when thd surgical drape is removed)
blood concentration of syndecan-1 at the end of the surgery
次要结局
- renal failure(STS GTSD 2.41 #3810)(within 30days after end of surgery)
- mortality(Status 30 Days after Surgery, STS GTSD 2.41 #3950)(30days post-surgery)
- initial ventilatory support greater than 48 hours (STS GTSD 2.41 #3520)(within 30days after end of surgery)
- pneumonia (STS GTSD 2.41 #3460)(within 30days after end of surgery)
- Unanticipated Post-Operative Invasive Procedure (STS GTSD 2.41 #3330)(during this 1 day hospital visit.)
- Anastomotic leak following esophageal surgery(STS GTSD 2.41 #3350)(within 30days after end of surgery)
- Respiratory Failure(STS GTSD 2.41 #3480)(within 30days after end of surgery)
- Acute kidney injury(within 48 h after end of surgery)