Effects of discontinuation of long-term benzodiazepine use on cognitive function in schizophrenia

Not Applicable

• Conditions: schizophrenia

• Registration Number: JPRN-UMIN000004008
• Lead Sponsor: Department of Neuropsychiatry St. Marianna University School of Medicine

Brief Summary

BZDs were reduced or discontinued safely in most patients, and no emergent withdrawal symptoms were observed. Significant improvements were shown in verbal memory, working memory, and composite score, as measured by the BACS-J without practice effects. In addition, the motivation/energy score on the SQLS-J, the negative symptoms and total scores on the PANSS significantly improved after tapering BZDs.

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2010-09-01
• Study Completion: 2012-01-01
• Last Update Posted: 17 October 2023

Recruitment & Eligibility

• Status: Complete: follow-up complete
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

Not provided

Exclusion Criteria

1) comorbid central nervous system disorder 2) meeting DSM-IV-TR criteria for alcohol or other substance dependence 3) meeting DSM-IV-TR criteria for mental retardation 4) taking tricyclic antidepressants 5) treatment with electroconvulsive therapy in the 3 months preceding the study; and 6) inability to understand the study protocol

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Cognitive function: Brief Assessment of Cognition in Schizophrenia-Japanese version (BACS-J)

Secondary Outcome Measures

Name	Time	Method
Psychopathology: Positive And Negative Syndrome Scale (PANSS), Clinical Global Impression- Severity (CGI-S) Subjective QOL: The Schizophrenia Quality of Life Scale -Japanese version (SQLS-J) Adverse effects: Drug-Induced Extrapyramidal Symptoms Scale (DIEPSS)