Influence of intravenous versus oral administration, arterial versus venous sampling and gender on pharmacokinetic-pharmacodynamic modelling of morphine and morphine-6-glucuronide-induced pain relief in healthy volunteers
Completed
- Conditions
- Post-operative painNot ApplicablePain
- Registration Number
- ISRCTN80473151
- Lead Sponsor
- eiden University Medical Centre (LUMC) (Netherlands)
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 60
Inclusion Criteria
Healthy volunteers, aged 18+ years
Exclusion Criteria
1. Body mass index (BMI) greater than 30 kg/m^2
2. Pregnancy or lactation
3. Presence of medical disease
4. Presence of psychiatric disease
5. Allergy to study medication
6. History of drugs or alcohol abuse
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Pain relief related parameters (Visual Analogue Scale [VAS] to heat pain) in males versus females.
- Secondary Outcome Measures
Name Time Method PK parameters<br>